Kris Jenkins- Jets- Even though the Jets have experienced his absence before, it is still a major blow to a defense that is starting to lose players on the D-Line.
Ryan Grant- Packers- With Grant gone, the Packers are essentially going to throw the ball every time. Brandon Jackson and John Kuhn will not be good enough to get it done. Look for a trade made on the Packer's part.
Bob Sanders- Colts- The surprise for the Colts in week 1 was their loss to Houston, not Sander's injury. He has been off and on with his injuries, and the Colts are used to not relying on him.
Jamaal Jackson and Leonard Weaver- Eagles- 2 key players from the Eagles blocking scheme hurts bad, as their seasons' are lost. Plus, there is still more uncertainty, with QB Kevin Kolb out.